| 초록 |
Recently, the photothermal effect using nanomaterials has been attracted as an efficient strategy for the next-generation of medical treatment. Photothermal therapy relies on the activation of photosensitizing materials by laser irradiation at Near-Infrared (NIR) to generate heat for the thermal ablation of bacteria or cancer tumors. In dental treatment, photothermal therapy has been considered an efficient method owing to its non-destructive properties. Herein, we propose that high-ordered TiO2 nanotubes were synthesized via a facile one-step anodizing method for photothermal therapy preventing peri-implantitis. The average pore size of anodized TiO2 nanotubes, 400℃ annealed TiO2 nanotubes, and 600℃ annealed TiO2 nanotubes were determined to 85.0, 86.2, and 84.2 by scanning electron microscopy (SEM), respectively. From the X-ray diffraction (XRD) analysis, the anodized TiO2 nanotubes show only titanium peaks due to amorphous structure. On the other hand, 400℃ and 600℃ annealed TiO2 nanotubes samples show the anatase and anatase/rutile TiO2 crystal structures, respectively. Under 808 nm laser irradiation, the 600℃ annealed TiO2 nanotubes revealed the highest increasing temperature of 21.8℃ among the samples for 4 min. These results show that 600℃ annealed TiO2 nanotubes have a superior photo to thermal conversion properties owing to anatase/rutile dual TiO2 crystal structures. As a result of quantitative analysis of streptococcus mutans adhesion by live/dead bacteria viability test, the total amount of bacteria tends to decrease in 400℃ and 600℃ annealed TiO2 surface compared to TiO2 nanotubes under 808 nm laser irradiation. |
