| 초록 |
Interest in the formation of well-defined nanostructures using block copolymers(BCPs) has been one of the mainstays in polymer chemistry over the past few decades. Many studies have been made on the synthetic strategies and self-assembly behavior of block copolymers. A widely used strategy to stabilize a microphase separated block copolymer self-assembly in solution involved cross-linking of the core-forming block. Despite the utility of core cross-linked BCP micelles, their synthesis through ring-opening metathesis polymerization(ROMP) has been relatively scarce. Herein, we report the preparation of core cross-linked BCP micelles through ROMP using a bifunctional monomer and a water soluble monomer. Various parameters, such as concentration, degree of polymerization, and order of monomer addition has been studied along with their effect on molecular weight and micelle properties. These micelles from amphiphilic block copolymers look promising to poorly soluble pharmaceuticals. |
