| 초록 |
Marine mussel adhesion is known to be mediated by mussel adhesive proteins (MAPs), which are secreted through the mussel byssus and have great potential as biologically and environmentally friendly biomaterials due to their biocompatibility and biodegradability. In addition, MAPs have strong adhesion ability even on wet surfaces due to unique amino acid arrangements and composition. However, researches using the natural amino acid composition of MAPs have been limited because of difficulties in obtaining sufficient quantities of MAPs for practical applications. Recently, we successfully and massively produced genetically redesigned new fusion MAP using a bacterial expression system, and this fusion protein showed significant adhesion ability. In addition, using the superior cell adhesion properties and fusion technology of the bioactive extracellular matix (ECM) peptides, we discovered the great potential of MAPs as bio-functional biomaterials for tissue and biomedical engineering applications. Adhesion of cells to a surface is a basic and important requirement in the fields of cell culture and tissue engineering. We developed several specialized cell adhesives based on MAPs and several ECM peptides. In this presentation, we will also demonstrate the multi-functional roles of MAPs as coating materials for implants and scaffolds as well as components of nanofibrous scaffolds. |
