| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Stepwise-drug release behavior of onion-like vesicles based on assembly of semicrystalline amphiphiles |
| 초록 |
Tailoring unique nanostructures of biocompatible and degradable polymers and the consequent elucidation of shape effects in drug delivery open tremendous opportunities not only to broaden their biomedical applications but also to identify new directions for the design of nanomedicine. Herein, aqueous onion-like vesicles structurally mimicking multicompartmentalized cellular organelles by exhibiting exquisite control over the molecular assembly of semicrystalline amphiphiles will be introduced. In particular, onion-like vesicles composed of alternating walls and water channels are interpreted by nanometer-scale 3D visualization via cryogenic-electron tomography. Interestingly, the nature of the multi-walled vesicles results in high drug-loading capacity and stepwise drug release through hydrolytic cleavage of the core block. |
| 저자 |
이은지 |
| 소속 |
충남대 |
| 키워드 |
vesicles; nanostructures; self-assembly; drug-release; supramolecular hybrids
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| E-Mail |
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