| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Novel ‘Click’ Hydrogel from Polyaspartamide Derivatives for Biomedical Applications |
| 초록 |
Copper-assisted azide alkyne cycloaddition (CuAAC) became lately a very interesting tool for synthesizing biocompatible polymer-based materials such as hydrogels and biocongugates. The alkyne group-modified polyaspartamide could be obtained by successful aminolysis reaction of polysuccinimide, anhydro polyaspartic acid, using propargyl amine. Tri-arm azido glycerol hydroxylates with pH-sensitive piperazine moiety were used as the crosslinker to prepare click gels. The obtained hydrogels will have the different behaviors in terms of swelling degrees, mechanical properties, and gel morphology. These novel hydrogels have potential for biomedical applications including controlled drug delivery and tissue engineering. |
| 저자 |
김지흥, Ngoc-Thach Huynh, 전영실
|
| 소속 |
성균관대 |
| 키워드 |
Hydrogel; Click reaction; poly(amino acid); pH-sensitive; swelling
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| E-Mail |
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