| 초록 |
Much attention has been paid to pH-sensitive drug delivery systems such as tumor targeting anticancer drug delivery, because it was reported that the extracellular pH of tumors is approximately 6.5~7.0, which is lower than that of normal tissues (pH 7.4). The purpose of this research to prepare of novel pH-sensitive poly(amino acid) derivatives as a carrier for doxorubicin and to study their drug release behavior. Amphiphilic polyaspartamide derivatives were synthesized by a successive graft reaction of hydrazine, O-(2-aminoethyl)-O’-methylpolyethylene glycol on polysuccinimide, and conjugeted doxorubicin with linkers of acid-sensitive hydrazone bond, doxorubicin release profile was investigated at various pHs by HPLC method. They also showed doxorubicin loading efficiency and triggered drug release behavior at acidic pH. These pH-sensitive polymers are a potential candidate for tumor targeting drug delivery carrier which require a triggered release system. |
