| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Spleen Dendritic Cell Activation by Modular Delivery of CpG-Incoporated DNA Nanoparticle |
| 초록 |
We introduce a versatile carrier system based on DNA nanoparticles (NPs). Incorporation of lipid-modified nucleobases to DNA strands enables formation of micelles in uniform size, in a single self-assembly step the micelles can be equipped with immune adjuvant (CpG) and fluorescent probe through Watson-Crick base-pairing. With the NPs we have investigated effect of the CpG concentration in immunostimulation. We observed dose dependent activation of TLR-9 resulting in DC maturation in vivo. |
| 저자 |
Mila Irva Sari1, Jun-O jin2, 곽민석1
|
| 소속 |
1Pukyong National Univ., 2Yeungnam Univ. |
| 키워드 |
Dendritic Cell; Immunology; Nanoparticle; DNA nanotechnology
|
| E-Mail |
|
