| 초록 |
The biomedical technologies utilizing DNA nanomaterials, including molecular imaging tools and nanomedicine, have immense potential to be successfully adopted in translational research. As a DNA-derived nanomaterial, self-assembled DNA nanostructure is a very attractive platform because its size and shape can be precisely controlled by using the base complementarity of DNA. Among known DNA nanostructures, the DNA tetrahedron has been considered one of the most practical DNA nanostructures since it can be self-assembled simply from four DNA strands and prepared in a high yield. We employ DNA tetrahedron derivatives as a carrier for delivery of biologically interesting molecules such as anticancer agents, proteins, and therapeutic oligonucleotides to the desired loci in the in vitro and in vivo system. In this presentation, the recent research achievement using the DNA tetrahedron as a carrier for therapeutic molecules and an imaging agent will be introduced. |
