| 학회 |
한국화학공학회 |
| 학술대회 |
2003년 가을 (10/24 ~ 10/25, 한양대학교) |
| 권호 |
9권 2호, p.1841 |
| 발표분야 |
분리기술 |
| 제목 |
Preparation of Nano- and Microparticulate Drug Delivery System Using Supercritical Fluid Technology |
| 초록 |
The objective of this study was to prepare drug-loaded biodegradable L-PLA microspheres using supercritical fluid and to evaluate their in vitro drug release characteristics. The effects of the drug to polymer ratio and blending with other biodegradable polymers such as PEG, DL-PLA and DL-PLGA on the formation and drug release of microspheres were investigated in detail. The Particle size was found to decrease with increasing drug to polymer ratio. It was also revealed that the particle size not only increases but the particle morphology also becomes more agglomerated as the amount of biodegradable polymers blended with L-PLA increases. The recovery of the microspheres was observed to be over 70% at all experimental conditions. The highest drug encapsulation efficiency and release rate were obtained to be 91% and 95% for one month, respectively, when ratio of drug to L-PLA was 20%. Furthermore, under the same condition, the release profile was found to follow the zero-order kinetics with a correlation coefficient of 0.987. |
| 저자 |
임교빈1, 김재훈2, 이상윤3, 김병용2, 유종훈1
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| 소속 |
1수원대, 2경희대, 3연세대 |
| 키워드 |
Supercritical carbon dioxide;Drug Delivery System; Biodegradable polymer; Poly(L-lactide); poly(D; L-lactide-co-glycolide);Microsphere
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| E-Mail |
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| 원문파일 |
초록 보기 |
