| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 봄 (04/04 ~ 04/06, 대전컨벤션센터) |
| 권호 |
43권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Activated dendritic cells delivered in biocompatible scaffolds induce extranodal activation of anti-tumor CTL responses leading to tumor regression |
| 초록 |
Dendritic cell (DC) based anti-cancer immunotherapy is well tolerated in patients with advanced cancers. DC based vaccines can benefit from cell delivery that would prevent the direct exposure to suppressive tumor microenvironments. Here we evaluated the ability of DCs harbored in biocompatible scaffolds (referred as beDCs) in activating specific anti- tumor immune responses against primary and post-surgery secondary tumors. Using a preclinical cervical cancer and a melanoma animal model, we show that single treatment of primary and post-surgery secondary tumors using beDCs resulted in significant tumor growth retardation while multiple inoculations were required to achieve a significant anti-tumor effect when DCs were given in free form. Remarkably, a strong immune cell infiltration into the host-implanted DC-scaffold was observed. The beDCs induced the anti-tumor immune responses in the absence of any stromal cell support, and the biomatrix was eventually absorbed into host tissue. |
| 저자 |
이준행 |
| 소속 |
Clinical Vaccine R&D Center and Department of Microbiology |
| 키워드 |
Cancer immunotherapy; Dendritic cell; Biomatrix; Tertiary lyphoid organoid
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| E-Mail |
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