| 초록 |
The biodegradable polylactides (PLA) homo- and copolymers have attracted much attention as materials for drug delivery system. They were biodegradable, and were classified as minimally toxic and not showed to cause adverse tissue reaction. There was no need to retrieve or retreat the carrier after drug depletion. Modification of PLA by polyethylene glycol (PEG) increased the degradation rate and hydrophilicity of the polymer carriers. PEG segments in the PLA copolymers can also enhance the diffusivity of drug in the polymer carriers. In this study, the effect of PEG segments added to the PLA microcapsules on the degradation, size distribution, and release rate were investigated. As a result, the mean diameter of prepared microcapsules was 40 ㎛ and spherical forms were observed by image analyzer and scanning electron microscope (SEM). And the particle size of the PLA microcapsules was smaller than that of PLA/PEG microcapsules under the same conditions. Drug release rate of PLA/PEG microcapsules was faster than that of PLA microcapsules because of higher hydration rate and swelling characteristics of the ethylene glycol. |
