| 학회 |
한국공업화학회 |
| 학술대회 |
2012년 가을 (10/31 ~ 11/02, 대전컨벤션센터) |
| 권호 |
16권 2호 |
| 발표분야 |
포스터-생물공학 |
| 제목 |
In vivo Tumor-targeted Imaging by Heavy Metal-free Quantum Dots Encapsulated within Human Serum Albumin Nanocapsules |
| 초록 |
We introduce a shell cross-linked protein-polymer hybrid nano capsule (NC) as an efficient intratumoral delivery vehicle for highly luminescent Cu0.3InS2/ZnS (CIS/ZnS) quantum dots (QDs). CIS/ZnS-loaded NCs are prepared by emulsifying amine-reactive six-armed polyethylene glycol (PEG) in dichloromethane into aqueous solution containing human serum albumin (HSA). The resulting NCs are stable even in the presence of serum and exhibit the luminescence of QDs comparable with that in non-polar organic solvent, indication high dispersion stability of the NCs. Folic acid (FA) is introduced as a target ligand to facilitate intratumoral uptake of CIS/ZnS-loaded HSA/PEG NCs. In several types of cells, the CIS/ZnS-loaded HSA/PEG NCs show reduced QD-induced cell death compared with cadmium selenide-cored QDs. The in vivo distribution of the CIS/ZnS QDs was monitored for 24 hours after tail vein injection into mice. |
| 저자 |
이정유, 최형석, 남윤성
|
| 소속 |
KAIST |
| 키워드 |
Bioimaging; Quantum dots; Tumor; Albumin; Folate
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| E-Mail |
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