| 학회 |
한국고분자학회 |
| 학술대회 |
2003년 봄 (04/11 ~ 04/12, 연세대학교) |
| 권호 |
28권 1호, p.56 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Supramolecular-structured polyrotaxane derivatives as novel blood compatible polymers |
| 초록 |
A polyrotaxane (PRx), a representative supramolecular architecture, consists of cyclic molecules with high potency for chemical modification and polymeric chains capped with bulky-end groups. This study involves the design of supramolecular-structured PRx derivatives as novel blood compatible polymers and their evaluation for biomedical applications. PRxs in which a-cyclodextrins (a-CDs) are threaded onto poly(ethylene glycol) (PEG)-block-poly(propylene glycol) (PPG)-block-PEG triblock copolymers capped with bulky-end groups, were prepared and chemically-modified by the introduction of sulfonate-containing groups to a lot of hydroxyl groups in a-CDs. PRx derivatives containing the sulfonate groups showed the synergistically enhanced anticoagulant activities. The incorporation of PRx derivatives lead to the changes of surface/bulk properties. Biocompatibility of the PRx derivative-immobilized surfaces was evaluated in vitro. |
| 저자 |
박형달;Tooru Ooya;Nobuhiko Yui;박기동;김영하 |
| 소속 |
Department of molecular science and technology |
| 키워드 |
polyrotaxane; blood compatible; sulfonate
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| E-Mail |
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