| 초록 |
Polyetheretherketone(PEEK), one of the potential alternatives to metallic materials for implants, necessarily involves high temperature process conditions to be 3D printed. We developed Hydroxyapatite coated PEEK/titanium(Ti) scaffolds by 3D printing. To enhance the interfacial biocompatibility, the as-printed implants were postprocessed with hydroxyapatite(HA) sputtering. The HA-coated surfaces were evaluated through characterization studies For the in vitro tests, preosteoblasts were cultured on the developed PEEK-Ti-HA structures and evaluated in terms of cell adhesion, proliferation, and osteogenic differentiation. In addition, the bone regeneration capability of the PEEK-Ti-HA implants was confirmed by animal experiments using a rabbit tibia defect model for a period of 8 weeks. Taken together, the comprehensive manufacturing approaches that involve 3D printing and biocompatible postprocessing are expected to have universal applicability in a wide range of bone tissue engineering. |
