| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
Inhibition of tumor growth by 5-fluorouracil and hydrogel as drug depot |
| 초록 |
While administrating anticancer drug for treatment, normal tissue can be affected by dose limiting problem. So, we prepared biodegradable MPEG-b-(PCL-ran-PLLA)(MCL) hydrogel and measured viscosity for the evaluation of thermo-sensitive property. In vivo antitumor activity was performed with 5-fluorouracil(5-FU)-loaded MCL, single and repeated intratumoral injection of 5-FU solution in tumor. The remaining amount of 5-FU drug was measured using HPLC after the removal of tumor from each mouse. For cytotoxicity test WST-1 assay was performed where as for histological analysis H&E and TUNEL processes were performed respectively. The findings in this experiment showed that 5-FU-loaded MCL can act as a biodegradable drug depot. Finally, this work indicates that intratumoral injection of 5-FU-loaded MCL allowed 5-FU to act effectively in the tumor and induced long-lasting inhibition of tumor growth. |
| 저자 |
판타 프라삼사, 김다연, 손아름, 김문석
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| 소속 |
아주대 |
| 키워드 |
injectable hydrogel; 5-fluorouracil
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| E-Mail |
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