| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO)) |
| 권호 |
23권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Thermo-sensitive polymer composed with photosensitizer for thermal and photodynamic dual therapy |
| 초록 |
Photodynamic therapy (PDT) is known as treatment of a variety of diseases, especially cancer therapy. PDT uses photosensitizer (PS) that generate Reactive Oxygen Species when PS was irradiated light. However, it has been limited due to low tumor targeting and poor water solubility. To overcome these drawbacks, we have developed PS conjugated thermo-responsive polymer (PTRP) without side effects. PTRP was comprised PS and polymer. At various temperature, thermosensitive polymer changed its shape. To confirm change, we used the small-angle X-ray scattering. PTRP has a lower critical solution temperature in water. When it was heated, it suffers a phase transition from random-coil to collapsed form. Consequently, fluorescence, singlet oxygen generation were increased at 45 °C than at 37 °C. In vitro cytotoxicity was measured at different temperatures, induced cell death at hyperthermia condition. |
| 저자 |
임병준1, 박우람2, 박신정1, 신희준1, 정영석1, 이병두3, 김동현4, 나건1
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| 소속 |
1가톨릭대, 2차의과대, 3Argonne National Laboratory, 4Northwestern Univ. |
| 키워드 |
Photodynamic therapy; Photosensitizer
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| E-Mail |
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