| 초록 |
Polymorphismis the ability of a solid material to exist in more than one form or crystal structure. Polymorphism is important in the development of pharmaceutical ingredients. Many drugs receive regulatory approval for only a single crystal form or polymorph and organic materialswith the medicinal effecthave thedifferentphysical properties of a medicineaccording to their shape.So it is important to control a crystal form.In this study, inorder toget the optimal control strategy, the effectof theoperating conditions such as the cooling rate, the stirring rate and the solvent conditions on a polymorph is investigated withmannitolusedfor an osmotic diuretic agent, and then the optimal control stratedgy is found. |
