| 초록 |
The extremely small-sized iron oxide nanoparticles (ESIONs) of ＜ 4 nm in diameter were synthesized by thermal decomposion of iron-oleate complex adding oleyl alcohol. These nanoparticles had low magnetism for their small magnetic moment and spin-canting effect. ESIONs were transfer to water by capping with PO-PEG and they have no significant cytotoxicity. ESIONs exhibited a high r1 relaxivity due to the small magnetism and large surface area of small particle, and high spin of iron atoms. In in vivo blood pool magnetic resonance imaging, ESIONs showed long term imaging than commercial gadolinium complex. These results indicate the potential of ESIONs to serve as T1 magnetic resonance imaging contrast agents in clinical settings. |
