| 초록 |
Restenosis is the formation of new blockages at the site of angioplasty or stent placement. In order to avoid this, the suppression of smooth muscle cells near the implanted stent is required. In this study, we have examined local non-viral gene delivery and therapeutic efficacy of proliferation inhibitory siRNA using HA-coated stents in a rabbit iliac artery restenosis model. To prepare proliferation inhibitory siRNA nanoparticles, the disulfide-crosslinked low molecular PEI(ssPEI), was used as a gene delivery carrier, because the disulfide bonds are stable in the oxidative extracellular environment but degrade rapidly in the reductive intracellular environment. It was observed that the proliferation inhibitory siRNA released from the stent suppressed the growth of the smooth muscle at the peri-stent implantation area, resulting in the prevention of restenosis at the post implantation. |
