| 초록 |
Microparticles of uniform size have been widely used for various fields such as drug delivery system, medical imaging agents and tissue engineering. In previous studies, golf-ball shaped microparticles were fabricated by small colloidal particles attached on the surface of microparticles. However, the previous studies cannot be applied to biodegradable polymers because of removal process of small colloidal particles by strong acids. We recently reported the fabrication of new structural microparticles with structural complexity both on the surface and inside by a simple O/W technique using PLGA. In this study, microparticles were fabricated with uniform size and structural complexity at both the surface of golf-ball-shaped and internal structure of porous. Our system can be applied to various polymers such as semi-crystalline biodegradable polymer, amorphous biodegradable polymers and non-degradable polymer. |
