| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
Smart Carriers for Bioactive Molecules and Cells(의료용 고분자 부문위원회) |
| 제목 |
Temperature-sensitive sol-gel transition polypeptide aqueous solutions for biomedical applications |
| 초록 |
Enzymatic degradation of the polypeptide while keeping hydrolytic stability in phosphate buffered saline makes these systems attractive to biomedical applications including as drug delivery and tissue engineering. Recently, we have developed polypeptide-based block copolymer aqueous solutions that undergo sol-to-gel transition as the temperature increases. Depending on the composition and molecular weight of the polypeptide, the secondary structure and enzymatic degradability of polypeptide could be controlled. Mechanism of sol-to-gel transition involves the secondary structural changes of polypeptide as well as the dehydration of the hydrophilic block. As an injectable depot system, protein delivery, three dimensional cell culture, and cell therapy were investigated. The in-situ formed gel provided a happy microenvironment for protein drug delivery and 3D culture of the incorporated cells. |
| 저자 |
정병문 |
| 소속 |
이화여자대 |
| 키워드 |
thermogel; drug delivery; 3D cell culture
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| E-Mail |
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