| 초록 |
This presentation will discuss our recent approaches to engineering biological systems to improve nanomedicine. First, we have developed drug delivery nanosystems where two distinct nanomaterials work in concert within the bloodstream to amplify tumor targeting and improve therapy in vivo, which was inspired by examples of communication in natural targeting systems (e.g. inflammatory cell recruitment to infection). Secondly, we have developed drug delivery nanosystems where tumor-derived membrane vesicles, which is an innate biological transport system, were engineered in situ to improve tumor penetration of therapeutic compounds and their therapeutic efficacy. |
