| 초록 |
There has been considerable interest in developing biodegradable nanoparticles using amphiphilic diblock copolymers as an effective hydrophobic drug carrier device. In this study, in order to increase the drug loading capacity compared to unfunctionalized PEO-PLA block copolymer, the PEO-PLA block copolymers containing a small quantity of carboxylic acid in the PLA block were synthesized. Also, the microscopic characteristics of nanoparticles with carboxylic acid content in the copolymers were analyzed, and the effect of specific interaction between copolymer and model drug on the drug loading capacity and the release behavior was investigated systematically. The sizes of nanoparticles prepared by a dialysis method are within the range of 30-40 nm. The nanoparticles prepared from functionalized block copolymer have a very low CMC value as 10-3 mg/ml, which indicates a good stability of the nanoparticle, in spite of the existence of carboxylic acid. The drug loading efficiency of nanoparticles was dramatically increased with increasing carboxylic acid content in the block copolymer. The release rate of drug was found to be much slower for nanoparticles containing higher amounts of carboxylic acid in the copolymer. These experimental results strongly suggest that the nanoparticles prepared from functionalized PEO-PLA block copolymer could be a good candidate for a injectable drug delivery carrier.
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