| 초록 |
Over the past decade, widespread progress in nanotechnology has produced an impressive array of nanodevices with powerful electromagnetic and therapeutic properties. Nonetheless, our capacity to precisely home these materials to regions of disease has remained very limited. A fundamental limitation of current approaches to nanoparticle targeting is that they lack mechanisms of communication and amplification through which specific targeting events could assist the targeting of materials still in circulation. Here, I will discuss development of nanosystems where a "cocktail" of two distinct nanomaterials work in concert within the bloodstream to amplify tumor targeting and improve therapy, which was inspired by examples of communication in natural targeting systems. I believe this work motivates a new paradigm of "systems nanotechnology" for biomedicine, where multi-component, interactive nanoparticle systems are engineered to improve the sensing and treatment of diseases in vivo. |
