| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Encapsulation of Protein Using Porous PLGA Microspheres |
| 초록 |
Porous poly(D,L-lactide-co-glycolide) (PLGA) microparticles were demonstrated to be used for sustained delivery of protein by entrapping protein inside the inner pores. The porous PLGA microspheres with less than 10 um in size were prepared by electrospraying. Aqueous solutions containing fluorescein isothiocyanate-dextran or bovine serum albumin were penetrated into the inner pores and then the outer surface pores of the PLGA microspheres were closed using a solvent (dimethyl sulfoxide) for sustained release. Confocal microscopy image confirmed the presence of a large amount of the macromolecules inside the porous structure. Circular dichroism spectroscopy and release analysis of protein revealed that the protein was entrapped without denaturation and released in a sustained manner for over one month, respectively. |
| 저자 |
백동현, 김주환, 최성욱
|
| 소속 |
가톨릭대 |
| 키워드 |
Protein delivery; electrospray; porous microparticles; sustained release
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| E-Mail |
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