| 학회 | 한국공업화학회 |
| 학술대회 | 2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 23권 2호 |
| 발표분야 | 포스터_생체재료 |
| 제목 | A self-assembled micellar immune inducer for cancer therapy with cationic amphiphilic polymers |
| 초록 | Today scientists are finding that cancer immunotherapy has a great possibility as a treatment for cancer; it increases innate immune system followed by having immune agents notice and eliminate cancer cells. Nevertheless, the cancer immunotherapy is limited to applicate for clinical use, similar to many other therapeutic proteins due to their low selectivity. Herein, we developed a self-assembled micellar immune inducer (SMI) for cancer therapy consists of cationic polymer which was conjugated with anionic polysaccharides that target cancer cell. The SMI was complexed via electrostatic interaction with anionic polysaccharide to remove toxicity of cationic polymer in normal tissues and give them selectivity for cancer. To summarize that, the SMI was accumulated into cancer site, then exhibited anti-cancer effects through cationic charge-induced cellular membrane damage. Newly fabricated SMI can be profitable platform of cancer therapy and be also utilized for anti-cancer drug delivery. |
| 저자 | 심현준, 나건 |
| 소속 | 가톨릭대 |
| 키워드 | electrostatic interaction; necrosis; immunotherapy; amphiphilic polymers. |
