| 초록 |
In metabolic engineering industry, the systematic approach to find a novel pathway for production was a time-cost work. Therefore, we developed a systematic platform called EnzMatcher to design metabolic pathways along with their candidate enzymes. Also, this platform identifies novel and feasible biosynthetic pathways for the target chemicals. For demonstration, we chose 6 chemicals and each chemical production pathway was predicted by this framework. We assure that this platform would be an effective tool to be applied in synthetic biology and metabolic engineering research area. [This work was supported by the Technology Development Program to Solve Climate Changes on Systems Metabolic Engineering for Biorefineries from the Ministry of Science, ICT and Future Planning (MSIP) through the National Research Foundation (NRF) of Korea (NRF-2012M1A2A2026556 and NRF-2012M1A2A2026557).] |
