| 학회 |
한국고분자학회 |
| 학술대회 |
2006년 봄 (04/06 ~ 04/07, 일산킨텍스) |
| 권호 |
31권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
SIS/PLGA and Thermosensitive Hydrogel Scaffold for Tissue Engineered Biodisc |
| 초록 |
Small intestinal submucosa has been widely used as a biomaterial without immune rejection responses. We fabricated cylindrical PLGA/SIS scaffold depending on content of SIS by solvent cast/salt leaching method. Morphology of scaffold was characterized by SEM. The disc cell isolated from the spine of NewZealand white rabbit was seeded in the inner section of synthesized MPEG-PCL hydrogel, and the AF cell was seeded in the outer section. Cell proliferation of disc cell was evaluated by MTT assay. Characterization of disc tissue was confirmed by the histological staining. In SEM result, all fabricated scaffold had interconnected open pore. MTT assay indicated that the scaffold containing SIS has good cell proliferation. In H&E staining results, we confirmed that cell density was increased from 1 to 6 weeks. Hydrogel seeded NP was observed the more sufficient ECM than the outer section. Acknowledgements : This research was supported by KMOHW (0405-BO01-0204-0006) and SCRC (SC3100). |
| 저자 |
고연경1, 하현정1, 최방실1, 김순희1, 박기숙1, 김문석2, 이해방2, 이종문1, 강길선1
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| 소속 |
1전북대, 2한국화학(연) |
| 키워드 |
scaffold; SIS; hydrogel; tissue engineered biodisc
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| E-Mail |
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