| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
학생우수논문발표(박사과정) |
| 제목 |
Generic platform for colorimetric assay of melanocyte laden 3D hydrogel |
| 초록 |
A colorimetric assay for melanogenesis inhibition is demonstrated with polyethylene glycol tetraacrylate (PEG-4A) hydrogels embedding melanocyte cells. The cell-laden three-dimensional (3D) PEG-4A hydrogel structure can be prepared by digital light processing (DLP) 3D printing using the visible range of light for improving biocompatibility. The melanocytes in the PEG-4A hydrogel show high cellular compatibility and expressed melanin, which changes the color of the hydrogel to black. Inhibition of melanin expression is evaluated by injecting different concentrations of arbutin and kojic acid into the cell-laden hydrogel structure in a 3D-printed microfluidic chip. It is demonstrated that the tyrosinase inhibitors prevent color change of the hydrogel pad and it can be used for an alternative monitoring tool of skin responsiveness in the future. |
| 저자 |
곽호정, 신성철, 현진호
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| 소속 |
서울대 |
| 키워드 |
colorimetric assay; melanocyte; Polyethylene glycol tetraacrylate; DLP 3D printing
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| E-Mail |
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