| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Methylene blue/fatty acid-complexed nanoparticles: A nanophotosensitizer with high efficacy in photodynamic therapy against breast cancer |
| 초록 |
Methylene blue (MB) has been used as a dye for staining living tissues and a photosensitizer for photodynamic therapy (PDT). Here, we report MB-assembled nanoformulations with enhancing photosensitizing ability and stability in-vivo condition. Using the electrostatic complexation of positive charged MB/negative charged fatty acid, the coaggregated methylene blue nanoparticles (MB NPs) with the average size of~100 nm were manufactured by aqueous self-assembly of a non-ionic surfactant (Pluronic F-68). The therapeutic efficacy of MB NPs was investigated by peritumoral injection in a xenotransplanted subcutanous tumor (MDA-MB-231, breast cancer) in female nude mice. We demonstrate that the MB nanophotosensitizer can efficiently induce cell death by apoptosis during PDT. |
| 저자 |
이용덕1, 방준하2, 김세훈1
|
| 소속 |
1한국과학기술(연), 2고려대 |
| 키워드 |
photodynamic therapy; methylene blue
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| E-Mail |
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