| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Development of Bilayered Nanofibrous Sheet Containing Chitosan for Anti-adhesion Barrier |
| 초록 |
Post-operative peritoneal adhesions are common and give serious complications for surgeons. They can cause pelvic pain, infertility, and potentially lethal bowel obstruction. This study was designed to evaluate the effect of bilayered nanofibrous sheet with nonsteroidal anti-inflammatory drug on the prevention of post-surgical tissue adhesion. For this, bilayered nanofibrous sheets composed of chitosan and PLGA were fabricated by electrospinning method. The bilayered Chitosan/PLGA nanofibrous mat was characterized by several spectroscopic methods. Cell culture results showed that bilayered nanofibrous mat decreased initial cell attachment and proliferation. From in vivo animal test, it was observed that bilayered nanofibrous mats were significantly effective in preventing post-operative adhesion and wound healing. |
| 저자 |
김선종1, 김원일2, 권오경3, 권오형1
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| 소속 |
1금오공과대, 2(주)원바이오젠, 3칠곡경북대 |
| 키워드 |
Anti-adhesion barrier; Electrospinning; Chitosan
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| E-Mail |
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