| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
고분자합성 |
| 제목 |
Hyaluronic Acids Attached with Methacrylates and 1, 2-Ditetradecanoyl-sn-glycero-3-phosphoethanolamine and Their Hydrogel Nanoparticles Synthesized via Surfactant-Free Inverse Microemulsion Mechanism |
| 초록 |
We covalently attach a lipophilic moiety of 1, 2-ditetradecanoyl-sn-glycero-3-phosphoethanolamine (DMPE) and UV-crosslinkable agents of methacrylic anhydride (MA) or 2-aminoethyl methacrylate (AEMA) to hyaluronic acid (HA), and demonstrate the successful formation of hydrogel nanoparticles via surfactant-free inverse microemulsion mechanism upon UV irradiation. The synthesis of methacrylated HA via ester bond (HA-MA) was performed in aqueous solution and DMPE modification with HA-MA via amide bond (HA-MA-DMPE) were carried out in a solvent mixture of THF, H2O and methanol solvent mixtures. Another HA derivative was prepared by substituting HA with AEMA and DMPE via amide bonds (HA-AEMA-DMPE). The hydrogel nanoparticles were synthesized using emulsification and particles were characterized by FESEM. The HA-MA-DMPE has produced better and uniform spherical hydrogel nanoparticles than HA-AEMA-DMPE upon UV irradiation. |
| 저자 |
윤정주, Ravi chandran, 김정태, 박주현
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| 소속 |
중앙대 |
| 키워드 |
Hyaluronic acid; DMPE; Hydrogel nanoparticle
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| E-Mail |
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