| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_생체재료 |
| 제목 |
Simultaneous chemo-photothermal therapy using injectable hydrogel as a therapeutic agent for rheumatoid arthritis |
| 초록 |
Hyperthermia can promote osteoblast differentiation and bone formation. In particular, hyperthermia combined with chemotherapy provides an effective treatment strategy for rheumatoid arthritis (RA). Herein, we proposed chitosan/gelatin/β-glycerol phosphate hydrogel containing melanin and methotrexate (CMM hydrogel), which can perform simultaneously chemotherapy and photothermal therapy as a therapeutic agent for RA. The CMM hydrogel was successfully formed at body temperature through sol-gel transition. Based on the intrinsic properties of melanin, it showed an effective temperature increase as the near-infrared (NIR) laser irradiation time increased in vitro and in vivo. After NIR laser irradiation, methotrexate release from the CMM hydrogel increased significantly. Consequently, the CMM hydrogel can be expected to be useful to improve drug release and promote therapeutic effect through hyperthermia for RA therapy |
| 저자 |
김민아1, 이호준1, 김예슬1, 박지선1, 김진2, 김동운3, 윤순도1, 이창문1
|
| 소속 |
1전남대, 2조선대, 3광양보건대 |
| 키워드 |
Rheumatoid arthritis; Chemo-photothermal therapy; Injectable hydrogels; Therapeutic agent
|
| E-Mail |
|
