| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 Ⅰ,Ⅱ |
| 제목 |
Characterization and evaluation of absorbable powder-type hemostatics containing blood coagulation factors |
| 초록 |
Absorbable chitosan (Cs)/starch (St) powder provides a wide range of fascinating benefits such as biocompatibility, blood coagulability, easy handling. In this study, we designed powder-type absorbable hemostatic agent containing CaCl2 and thrombin. The crosslinked structure and morphology were determined using FTIR and SEM. In vitro whole blood coagulation experiment showed rapid blood coagulation within 1 minute after introduction with fabricated powder-type hemostatic because of absorption by calcium ion and thrombin. In vivo animal studies using haemorrhaging liver rat model showed that the Cs/St/CaCl2/thrombin group reduced bleeding time and hemorrhage quantity than control and commercial products groups. The powder-type Cs/St/CaCl2/thrombin hemostatics have effective hemostatic activity and biocompatibility properties for use in clinical hemostasis applications. |
| 저자 |
신인해, 김유진, 권오형
|
| 소속 |
금오공과대 |
| 키워드 |
powder-type; hemostatic; blood coagulation; wound healing
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| E-Mail |
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