| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 Ⅰ,Ⅱ |
| 제목 |
Multi-functional O-carboxymethyl chitosan Coatings with Superhydrophilicity for superior Antimicrobial, Antithrombotic Activity and Lubricity in Intravascular Catheters |
| 초록 |
Surface functionalization of the intravascular catheter for minimally invasive surgery, must be performed due to the three critical issues: blood stream infection, thrombosis, and damage to blood vessels due to high friction. Currently, most of prior technologies can't prevent the three aforementioned issues at once, and use material having potential side effects. Here, we suggest multi-functional coating that can simultaneously implement antimcrobial, antithrombotic activity and low friction by coating with O-carboxymethyl chitosan (CMC). Especially, the coating layer was prepared in a porous structure to give the catheter surface super hydrophilicity, which showed a synergistic effect due to the anti-adhesion of bacteria and thrombin along with the inherent properties of CMC. Furthermore, the porous CMC coated catheter had sufficient lubricity in water, coating durability and high trackability in simulated blood vessels, demonstrating that it can be applied in practice catheters. |
| 저자 |
박세계1, 신재학2, 정재희2, 이동윤3, 최동윤1, 유승화4
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| 소속 |
1한국생산기술(연), 2세종대, 3경북대, 4전북대 |
| 키워드 |
Intravascular catheters; Multi-functional properties; Superhydrophilicity; Antimicrobial activity; Antithrombotic activity
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| E-Mail |
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