| 초록 |
In this study, the ion beam-based micropatterning of a hydrophilic polyelectrolyte on a hydrophobic polystyrene (PS) surface was investigated to control the cell adhesion. Thin films of poly(sodium 4-styrenesulfonate) (PSS) as a polyelectrolyte were formed on hydrophobic PS substrates through spin-coating 5 wt% PSS solution, and then were selectively irradiated with 200 keV proton ions through a patterned-mask. After that, the resulting substrates were developed with distilled water to form negative-type PSS patterns. Based on the surface analysis, 100 µm negative patterns of PSS were resolved on the PS substrates at fluences higher than 5 x 1014 ions/cm2 and their surface chemical properties were dependant on the fluence. Moreover, the results of the cell culture test revealed that cells were predominantly adhered to and proliferated on more hydrophilic PSS regions of the PSS-patterned PS substrate, resulting in well-organized cell patterns. |
