| 초록 |
This paper reports the synthesis of [18F]-nGO-PEG by covalently functionalizing PEG with nano-graphene oxide, and its excellent stability in physiological solutions. Using a green synthesis route, nGO is then functionalized with a biocompatible PEG polymer to acquire high stability in PBS and DMEM. The radiochemical safety of [18F]-nGO-PEG was measured by a reactive oxygen species and cell viability test. The biodistribution of [18F]-nGO-PEG could be observed easily by PET, which suggested the significantly high sensitivity tumor uptake of [18F]-nGO-PEG and in a tumor bearing CT-26 mouse compared to the control. [18F]-nGO-PEG was applied successfully as an efficient radiotracer or drug agent in vivo using PET imaging. This article is expected to assist many researchers in the fabrication of 18F-labeled graphene-based bio-conjugates with high reproducibility for applications in the biomedicine field. |
