| 학회 |
한국화학공학회 |
| 학술대회 |
2006년 가을 (10/27 ~ 10/28, 고려대학교) |
| 권호 |
12권 2호, p.2679 |
| 발표분야 |
제3회 약물전달(DDS) 기술과 응용 |
| 제목 |
Polymer Nanoparticles for Targeted Cancer Therapy |
| 초록 |
Self-assembled nanoparticles based on hydrophobically modified glycol chitosan (HGC) were prepared as for cancer therap. HGC conjugates were prepared by chemically linking 5b-cholanic acid to glycol chitosan chains using 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide. In phosphate-buffered saline (PBS pH 7.4), the synthesized HGC conjugates formed nano-sized particles with a diameter of 200 nm and exhibited high thermodynamic stability. Paclitaxel was efficiently loaded into HGC nanoparticles to 10 wt% using a dialysis method. The paclitaxel-loaded HGC (PTX-HGC) nanoparticles showed high anti-tumor efficacy in vivo. |
| 저자 |
권익찬 |
| 소속 |
한국과학기술(연) |
| 키워드 |
nanoparticle; cancer therapy; drug delivery system
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| E-Mail |
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| 원문파일 |
초록 보기 |
