| 초록 |
Over the past years, nanoparticles have been known as common carriers for controlled drug release systems. Binding nanoparticles to metal surface may enable to make effective drug releasing medical devices. However, there are few studies that are focused on the adhesion or affinity between nanoparticles and metal surfaces. Herein, we describe a novel strategy to make metal-adhesive polymer nanoparticles for controlled drug release. These nanoparticles could easily adhere to metal surface by a simple dipping method without any additional chemical reactions and stably maintain their conformations. Successful immobilization of nanoparticles onto metal surface was confirmed by Fe-SEM analysis. Drug was loaded onto nanoparticles bonded to metal surface, and sustainably released as the feed amount. Metal-adhesive nanoparticles may have better drug releasing effect than current systems, and be expected to be used for medical devices. |
