| 초록 |
Alginate hydrogels can be easily formulated to carry drugs and/or cells by simple mixing followed by a chemical or physical curing process. Alginate hydrogels offer a wide range attractive benefits, as an easy to use medical device for various applications including drug delivery and tissue engineering. In this work, alginate hydrogels were fabricated by modification of alginate with tyramine and subsequent enzymatic crosslinking reaction. Their gelation, mechanical and degradation properties were systemically investigated by varying the concentration of horseradish peroxidase and H2O2. Rheological properties were also tested according to adjusting the amount of H2O2, HRP and concentration of modified alginate solutions. As a result, the modified hydrogels were successfully synthesized. The results for gelation time and mechanical strength revealed that both the rate and degree of cross-linking in hydrogels were fairly well controlled by changing the H2O2 and HRP concentrations. |
