초록 |
We synthesized the rod-like polymeric gold nanomaterials conjugated with DNA, and investigated their chemical and physical properties. Before the DNA conjugation, the polymeric gold nanomaterials were first reacted with chemical additives for the improvement of their mechanical and chemical stability. These chemical additives would be expected to attract more CTAB molecules, and thus, increase the zeta-potential of the rod-like polymeric gold to prevent their aggregation during the DNA conjugation process. Importantly, the polyvalent DNA–polymeric gold nanorod conjugates were synthesized based on the enhanced stabilities of polymeric gold nanorod induced by additives, and thoroughly investigated for their cooperative melting properties. Various experimental parameters such as the length and sequence of the DNA spacers, and ionic strength of the solution were examined and demonstrated to effectively control the melting properties of the polyvalent DNA–gold nanorod conjugates. |