| 학회 | 한국공업화학회 |
| 학술대회 | 2016년 봄 (05/02 ~ 05/04, 여수 엑스포 컨벤션) |
| 권호 | 20권 1호 |
| 발표분야 | 생물공학_포스터 |
| 제목 | Fabrication of Nano-biocapsule with siRNA and Au Nanorods for Breast Cancer Therapy |
| 초록 | Therapeutic nanomaterials have been extensively developed for the effective treatment of aggressive cancers because of their outstanding versatility, easy manipulation, and low cytotoxicity. In this study, we describe a nano-biocapsule of bovine serum albumin engaged with both Bcl-2–specific siRNA and an Au nanorods for targeted breast cancer therapy. The nano-biocapsule contained 2 × 105 siRNAs and eight Au nanorods per biocapsule and was successively functionalized with polyethylene glycol and anti-ErbB-2 for active targeting. The nano-biocapsule with intrinsic biocompatibility and multi-functionality is a highly promising therapeutic carrier for in vivo targeted cancer therapy and may have potential uses in various areas of nanomedicine. Acknowledgements: This work was supported by the National Research Foundation of Korea(NRF) grant funded by the Korea government(MSIP) (No. 2015R1A2A2A01007843). |
| 저자 | 이원진, 오병근 |
| 소속 | 서강대 |
| 키워드 | nanorods; siRNA; cancer therapy |
