| 학회 |
한국화학공학회 |
| 학술대회 |
2008년 봄 (04/23 ~ 04/25, 제주ICC) |
| 권호 |
14권 1호, p.504 |
| 발표분야 |
생물화공 |
| 제목 |
Electrical Detection of β-amyloid Based on Scanning Tunneling Microscopy |
| 초록 |
The Beta-amyloid 1-40 is most challenging marker for the early diagnosis of Alzheimer disease. In the present study an STM(scanning tunneling microscopy) based electrical detection method for β-amylod 1-40 was developed. Au nanoparticle and antibody complex was used for this STM based Immunosensor. The frequency of the tunneling current peaks was measured in accordance with the surface density of the dispersed gold nano-particle antibody complex on the gold electrode. As a result a periodgram with its logarithmic regression curve and the change of power spectrum was observed with various concentration of the marker molecule. The lowest detection limit of the developed immunosensor was found to be 1fg /ml. Acknowledgments: This research was supported by the Nano/Bio science & Technology Program (M10536090001-05N3609-00110) of the Ministry of Science and Technology (MOST), by Seoul Research and Business Development Program (10816), and by the Korea Government (MOST) (2006-05374). |
| 저자 |
이진호, 강다연, 김상욱, 예철헌, 오병근, 최정우
|
| 소속 |
서강대 |
| 키워드 |
Scanning Tunneling Microscopy; Alzheimer; β-amyloid; Immunosensor; nano-particle
|
| E-Mail |
|
| 원문파일 |
초록 보기 |
