| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Thermosensitive nanofiber using Pluronic F127 for sustain release of drug |
| 초록 |
In this study, thermosensitive poly(ε-caprolactone)/poly(ε-caprolactone)-poly (ethylene glycol-(amine)2) nanofiber [PCL/PCL-PEG NF] conjugated with Pluronic F127 used for loading and release dexamethasone. PCL-PEG block copolymer was mixed with PCL for electrospining by different blending ratio of PCL-PEG from 0% to 100%. And F127 was conjugated to exposed amine group on the PCL/PCL-PEG NF as molar ratio 1:1. In order to characterize Pluronic F127 conjugated PCL/PCL-PEG NF, contact angle, 1H NMR and release test was performed. 1H NMR showed PEO peak at 3.4 ppm in PCL/PCL-PEG-F127, which was not detected in control group. mPEG-FITC micelle was loaded on nanofiber at 4°C and 37°C and released in 1X PBS at 37°C. As the result, more than 5% (w/w) of drug was released out from PCL/PCL-PEG-F127 compared with control for 30days. Therefore, F127 conjugated PCL/PCL-PEG NF will be appropriate device to coat the surface of stent and release drug such as dexamethasone. |
| 저자 |
최지숙, 유혁상, 손영주, 김혜성, 윤수진, 조은주
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| 소속 |
강원대 |
| 키워드 |
thermo-sensitive; nanofiber; sustain release
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| E-Mail |
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