| 초록 |
The main function of bone cement is to stabilize prosthesis by filling the gap between the prosthesis and the surrounding bone and to transmit loads from the prosthesis to the bone. PMMA bone cement, which was widely used in orthopedic surgery, has no ability for bone bonding, leading to aseptic loosening of the cement, caused by both mechanical and biological factors. In order to solve these problems, several biodegradable bone cements with normal bone healing and remodeling processes and improved physical properties have been developed. In the present study, we have prepared the novel biodegradable bone cements based on Bis-GMA and its derivatives (3MA and 4MA) as prepolymer, biodegradable materials as additive, and AW-GC as bioactive ceramic filler. Incorporated biodegradable materials may create a porous cement as the implantation time increases, which could facilitate bone regeneration. As compared with Bis-GMA control, the novel biodegradable bone cements with an appropriate ratio of polymerization initiator, promoter, and inhibitor were characterized by evaluating curing time, polymerization shrinkage, as well as mechanical properties. |
