| 학회 |
한국화학공학회 |
| 학술대회 |
2007년 가을 (10/26 ~ 10/27, 한국과학기술원) |
| 권호 |
13권 2호, p.2603 |
| 발표분야 |
제4회 약물전달(DDS) 기술 심포지엄 |
| 제목 |
Biodegradable Nanoassembly for Protein and Anticancer Drug Delivery |
| 초록 |
Recent progress in polymer nanotechnology has been directed to the application of biodegradable nanoparticles based on natural proteins and polysaccharides as drug delivery systems, due to their biodegradation, sustained-release properties, sub-cellular size and stability. In the present study, we developed two biodegradable nanosize drug carriers. Recombinant human gelatin-based nanoparticles were prepared by a simple coacervation method, which are suitable for the hydrophilic protein drug delivery. In addition, a hydrophobically modified glycol chitosan (HGC) was prepared by a conjugation of glycol chitosan with 5β-cholanic acid. In aqueous phases, the HGC conjugates formed nanoparticles. Their hydrophobic cores were surrounded with a hydrophilic outer domain. The inner domain can serve as a nano-reservoir for a variety of hydrophobic anticancer drugs. The characteristics of nanoparticles were investigated by various physicochemical techniques to examine the possibility as drug carriers. These results represent that novel nanoassemblies are appropriate for protein and anticancer drug delivery. |
| 저자 |
김용희1, 황호영1, 원영욱1, 권익찬2, 김광명2
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| 소속 |
1한양대 생명공학과, 2한국과학기술(연) |
| 키워드 |
Drug Delivery; Nanoassembly; Protein; anticancer drug
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| E-Mail |
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| VOD |
VOD 보기 |
| 원문파일 |
초록 보기 |
