| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Hydrotropically Modified Hyaluronic Acid Nanoparticles for Targeted Drug Delivery System |
| 초록 |
The therapeutic application of many potential drugs and drug candidates with high biological activities has been limited by their poor water solubility. In this study, we have synthesized hyaluronic acid (HA) derivative bearing hydrotropic moieties, by grafting nicotinamide-based hydrotropic oligomers to HA. The physicochemical properties of the system were investigated using 1H NMR, dynamic light scattering and fluorospectrophotometer. The degree of substitution of the oligomers to HA has been varied and evaluated for aqueous solubility of paclitaxel. This particular system can be useful as the targeted delivery of the poorly water soluble drugs. |
| 저자 |
G. Saravanakumar1, 최기영1, 이상천2, 김광명3, 박재형1, 권익찬3, Kinam Park4
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| 소속 |
1경희대, 2요업(세라믹)기술원 나노소재응용본부, 3한국과학기술(연), 4School of Pharmacy |
| 키워드 |
Hyaluronic acid; Drug delivery
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| E-Mail |
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