| 학회 |
한국고분자학회 |
| 학술대회 |
2006년 봄 (04/06 ~ 04/07, 일산킨텍스) |
| 권호 |
31권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
In vivo Tumor Targeting and Nuclear Imaging with Self-assembled Nanoparticles |
| 초록 |
The development of more selective drug delivery systems is one of the most important goals of current anticancer research. We herein describe a highly effective tumor-targeting strategy utilizing self-assembled nanoparticles. By combining different hydrophobic moieties and hydrophilic polymer backbones, various self-assembled nanoparticles were prepared, and their in vivo distributions in tumor-bearing mice were studied by gamma scintigraphy. The multiple factors to influence the tumor targeting were studied in terms of particle size, tumor type and vascular characteristics. The magnitude and pattern of tumoral accumulation of nanovectors are discussed with attention to their relevance to tumor angiogenesis, in this study. |
| 저자 |
조용우1, 박지선1, 한태희2, 이근용2, 안철희3, 변영로3, 권익찬4
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| 소속 |
1울산대, 2한양대, 3서울대, 4한국과학기술(연) |
| 키워드 |
Nanoparticle; Tumor Targeting; Nuclear Imaging
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| E-Mail |
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