| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 가을 (10/11 ~ 10/12, 일산킨텍스) |
| 권호 |
32권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Novel multifunctional PHDCA/PEI nano-drug carriers (MPDCs) for simultaneous magnetically-targeted cancer therapy and diagnosis via magnetic resonance imaging (MRI) |
| 초록 |
The MPDCs consist of ultra-sensitive magnetic nanocrystals as MR probes and for magnetic targeting, and a chemotherapeutic agent encapsulated in poly(hexadecylcyanoacrylate) (PHDCA) nanoparticles. The PHDCA nanoparticles were further coated with polycationic polyethylenimine (PEI) to enhance cellular uptake efficiency. Using organic solvent, 10.3 ±0.7 nm of monodisperse magnetic nanocrystals (Fe3O4) weresynthesized. To form the magnetic PHDCA nanoparticles (MPNs), magnetic nanocrystals in organic solvent and DOX were simultaneously encapsulated with the synthesized PHDCA using the emulsion solvent evaporation method. The anionic MPNs were coated with polycationic PEI. |
| 저자 |
서성백1, 양재문2, 윤호근2, 허용민2, 함승주2
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| 소속 |
1나노메디컬 협동과정 / 연세대, 2연세대 |
| 키워드 |
magnetic drug delivery; magnetic resonance imaging
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| E-Mail |
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