| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
22권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Reactive oxygen species-sensitive nanophotosensitizer based on methoxy poly(ethylene glycol)-b-hyaluronic acid copolymer for theranostic application of tumor |
| 초록 |
In this study, we synthesized methoxy poly(ethylene glycol)-b-hyaluronic acid (MePEG-HA) copolymer and conjugated chlorin e6 (Ce6) as a photosensitizer via diselenide linkages. Ce6-conjugated MePEH-HA copolymer (Abbreviated as HAbPEG-Ce6) formed nanoparticles having core-shell structure in the aqueous environment. HAbPEG-Ce6 nanophotosensitizer showed small particle sizes less than 100 nm and spherical shape in the morphological observation using TEM. HAbPEG-Ce6 nanophotosensitizer showed ROS-sensitive liberation of Ce6, i.e. Ce6 release was accelerated when hydrogen peroxide was added in the release media and revealed increased fluorescence activity. We suggest HAbPEG-Ce6 nanophotosensitizer as a promising candidate for tumor drug delivery of photosensitizer. |
| 저자 |
정경원1, 차병열2, 안준혁1, 홍웅길1, 정영일3, 나재운1
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| 소속 |
1순천대, 2김해 바이오메디칼 연구센터, 3양산 부산대 |
| 키워드 |
ROS; Nanophotosensitizer; block copolymer; chlorin e6
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| E-Mail |
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